Publications by authors named "C S Srinivasan"
Background: Oral cancer; categorised under head and neck cancers (HNC) predominantly originates from squamous cells and is referred as oral squamous cell carcinoma (OSCC). Various factors (internal and external) causes OSCC. PI3K/AKT/mTOR pathways are known to be primarily mutated in HNC.
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- Necrotizing fasciitis (NF) is a serious infection that needs quick diagnosis and treatment; the LRINEC score helps assess patient risk levels early on.
- A study in Chennai involving 112 NF patients found that 51.8% were at low risk, with significant links between higher LRINEC scores and worsening lab results, diabetes, and vascular disease.
- With proper treatment, 83.9% of patients improved with conservative methods, while complications like delayed healing occurred in some cases, highlighting the importance of the LRINEC score in clinical decision-making.
Article Synopsis
- - The case report discusses a 35-year-old woman who experienced multiple chronic discharging abdominal wall sinuses due to Prolene granuloma following a caesarean section.
- - Prolene granuloma is a rare inflammatory reaction to non-absorbable sutures that can result in painful masses and discharge, often detected long after surgery.
- - Surgical exploration revealed the granuloma and sinus tracts, which were successfully removed, underscoring the necessity for early diagnosis and intervention to manage post-surgical complications effectively.
There is a need to investigate novel strategies in order to create an effective, broadly protective vaccine for current and future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks. The currently available vaccines demonstrate compromised efficacy against emerging SARS-CoV-2 variants of concern (VOCs), short-lived immunity, and susceptibility to immune imprinting due to frequent boosting practices. In this study, we examined the specificity of cross-reactive IgG antibody responses in mRNA-vaccinated, AstraZeneca-vaccinated, and unvaccinated donors to identify potentially conserved, cross-reactive epitopes to target in order to create a broadly protective SARS-CoV-2 vaccine.
View Article and Find Full Text PDFBackground Inguinal hernia repair is a common surgical procedure addressing the protrusion of abdominal viscera through the inguinal canal. Despite advancements, complications such as chronic postoperative pain, infections, and hernia recurrence persist. Traditional sutured polypropylene mesh can cause nerve irritation and inflammation, leading to chronic pain and other issues.
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