Publications by authors named "C S Sheeba"
Purpose: The knowledge and attitude of participants toward clinical trials (CTs) are a key determinant in successful recruitment and retention. This study aimed to evaluate knowledge and awareness-attitude among the recruited CT participants about CTs.
Methods: This was a cross-sectional face-to-face survey comprising CT participants involved in the past or currently a part of a CT during this study within the Indian Ophthalmology Clinical Trial Network (IOCTN).
Introduction: Natural hair curvature and colour are genetically determined human traits, that we intentionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act externally and their recurrent use is quite detrimental to hair fibre quality and even to our health.
Objectives: This work represents a disruptive concept to modify natural hair colour and curvature.
Purpose: Advances in patient treatment depend heavily on clinical trials (CTs). Patient volunteers for CT are tougher to recruit and retain. In order to administer CTs effectively, it is necessary to comprehend how the public views and perceives participating in them.
View Article and Find Full Text PDFPurpose: The purpose of the study was to evaluate the knowledge and perception of health-care professionals (HCPs), such as doctors/surgeons, pharmacists, nurses, optometrists, and lab technicians, on clinical trials (CTs) in India.
Methods: The study was a pan-Indian cross-sectional survey initiated by the Indian Ophthalmology Clinical Trial Network (IOCTN) by using a previously validated questionnaire for three months of data collection. An online survey was used to record information regarding demographics, CT knowledge, and CT perception among HCPs.
Article Synopsis
- Transposable elements (TEs) are common in eukaryotic genomes, and their activity is usually regulated by piRNAs and chromatin, but how this regulation evolves is not well understood.
- Researchers studied C. elegans populations over 409 generations, finding that smaller populations exhibited increased TE expression due to less effective natural selection, leading to a failure of piRNA-mediated silencing.
- The study suggests that the epigenomic context influences TE silencing dynamics, providing new insights into how natural selection helps control TE expression levels in these organisms.