Publications by authors named "C S Reinbold"
Background And Aims: Adverse pregnancy outcomes (APO) have been related to increased cardiovascular (CV) risk and mortality in later life. Underlying pathomechanisms for the development of CV disease in these women are not yet fully understood. In this study, we aimed to investigate the relationship between APO and individual CV risk profiles in later life.
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- * Neuroimaging reveals that many of these genetic variants have widespread effects on brain regions and are linked to various cancers and specific signaling pathways, such as p53 and Wnt.
- * The findings suggest a connection between the genes that regulate head size and the likelihood of cancer, emphasizing the need for further research on the implications of this relationship.
Article Synopsis
- The stability and turnover of proteins are influenced by their N-terminal sequences and how these sequences are processed, potentially leading to degradation signals.
- Researchers can gain insights into the effects of genetic changes on protein stability through methods that assess many N-terminal proteins at once, such as using tandem fluorescent timers (tFT).
- The protocol described allows for Multiplexed Protein Stability (MPS) profiling in yeast by sorting and analyzing large libraries of proteins with different N-termini, ultimately generating a stability index for each variant through deep sequencing.
Selective degradation of unnecessary or abnormal proteins by the ubiquitin-proteasome system is an essential part of proteostasis. Ubiquitin ligases recognize substrates of selective protein degradation and modify them with polyubiquitin chains, which mark them for proteasomal degradation. Substrate recognition by ubiquitin ligases often involves degradation signals or degrons, which are typically short linear motifs found in intrinsically disordered regions, e.
View Article and Find Full Text PDFAims: The randomized Early Treatment of Atrial Fibrillation for Stroke Prevention Trial found that early rhythm control reduces cardiovascular events in patients with recently diagnosed atrial fibrillation (AF) compared with usual care. How genetic predisposition to AF and stroke interacts with early rhythm-control therapy is not known.
Methods And Results: Array genotyping and imputation for common genetic variants were performed.