Publications by authors named "C S Rabkin"
Background: The effect of initial antiretroviral therapy (ART) class on cancer risk in people with HIV (PWH) remains unclear.
Setting: Cohort study of 36,322 PWH enrolled (1996-2014) in the North American AIDS Cohort Collaboration on Research and Design.
Methods: We followed individuals from ART initiation (protease inhibitor [PI]-, non-nucleoside reverse transcriptase inhibitor [NNRTI]-, or integrase strand transfer inhibitor [INSTI]-based) until incident cancer, death, loss-to-follow-up, 12/31/2014, 85 months (intention-to-treat analyses [ITT]), or 30 months (per-protocol [PP] analyses).
Background: Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.
Methods: A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted.
Article Synopsis
- Prophages significantly influence the characteristics of pathogenic bacteria, yet their ecological and evolutionary roles, particularly in bacteria linked to gastric cancer, are not well understood.
- A comprehensive analysis of 1,011 complete clinical genomes revealed that 29.5% contain prophages, with only 32.2% being complete, and their distribution varies by geography and ancestry but not by the disease status of hosts.
- The study uncovered mechanisms of prophage inactivation and proposed a new model for regulating the lysogenic-lytic cycle, providing a deeper understanding of how prophages impact bacterial genetics and adaptation.
Background: Anemia is an independent predictor of mortality, which may be utilized as a signal of deteriorating health. We estimated the association between anemia severity categories and mortality following the initiation of antiretroviral therapy (ART) among people with HIV (PWH) in North America.
Methods: Within the NA-ACCORD, annual median hemoglobin measurements between January 01, 2007, and December 31, 2016, were categorized using World Health Organization criteria into mild (11.
Background: Although overall incidence of gastric cancer is decreasing, incidence has been increasing among young people in some Western countries. This trend may stem from the increase in autoimmune conditions.
Methods: A nested case-control study of gastric cancer in UK Clinical Practice Research Datalink.