A Network Analysis of Quality of Life Among Older Adults With Arthritis.

Introduction: Arthritis, one of the most common chronic diseases among older people, greatly impairs quality of life through a variety of physical and psychological challenges. This study used network analysis to gain a deeper understanding of the relationships between the indicators of quality of life in older adults with arthritis depending on duration of disease.

Methods: This cross-sectional study used data from 874 older adults with osteoarthritis and/or rheumatoid arthritis who answered the eighth (2019-2021) Korea National Health and Nutrition Examination Survey.

Brain energy homeostasis: the evolution of the astrocyte-neuron lactate shuttle hypothesis.

The brain's substantial metabolic requirements, consuming a substantial fraction of the body's total energy despite its relatively small mass, necessitate sophisticated metabolic mechanisms for efficient energy distribution and utilization. The astrocyte-neuron lactate shuttle (ANLS) hypothesis has emerged as a fundamental framework explaining the metabolic cooperation between astrocytes and neurons, whereby astrocyte-derived lactate serves as a crucial energy substrate for neurons. This review synthesizes current understanding of brain energy metabolism, focusing on the dual roles of lactate as both an energy substrate and a signaling molecule.

Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles.

Glioblastoma multiforme (GBM) is a devastating primary tumor of the central nervous system with a significantly poor prognosis. The primary challenge in treating GBM lies in the restrictive nature of the blood-brain barrier (BBB), impeding effective drug delivery to the brain. In this study, intranasal polymeric micelles encapsulating a quercetin-etoposide combination were developed to induce synergistic apoptotic effects and enhance direct drug delivery to the brain.

"The mannequins have been pink for a very long time." Navigating whiteness and realness in simulation.

Simulation training provides health professions learners access to training not readily available to them and in a manner that does not harm patients. Simulation also supports learners to develop dispositions and professional communication and reflect on their biases. This study examines how learners, clinical education faculty, and simulation professionals reflect on diversity and antiracism in simulation and contextualize these reflections with their lived experience.

The Efficacy of Organic Filter-Based Sunscreens in Alleviating Symptoms and Enhancing the Condition of Sensitive Skin.

Background: Sensitive skin causes discomfort from irritants, impacting quality of life. While hypoallergenic moisturizers help prevent moisture loss, some ingredients can still cause irritation. Treatments like steroids and calcineurin inhibitors have side effects, and chemical sunscreens can cause irritation in sensitive skin.