Publications by authors named "C S Olesen"
Experimental and numerical study of solid needle insertions into human stomach tissue.
J Mech Behav Biomed Mater
February 2025
Purpose: Oral drug delivery is the Holy Grail in the field of drug delivery. However, poor bioavailability limits the oral intake of macromolecular drugs. Oral devices may overcome this limitation, but a knowledge gap exists on the device-tissue interaction.
View Article and Find Full Text PDFCommunication between cells is largely orchestrated by proteins on the cell surface, which allow information transfer across the cell membrane. Super-resolution and single-molecule visualization of these proteins can be achieved by genetically grafting HTP (HaloTag Protein) into the protein of interest followed by brief incubation of cells with a dye-HTL (dye-linked HaloTag Ligand). This approach allows for use of cutting-edge fluorophores optimized for specific optical techniques or a cell-impermeable dye-HTL to selectively label surface proteins without labeling intracellular copies.
View Article and Find Full Text PDFArticle Synopsis
- Chronic HCV infection affects about 50 million people worldwide, leading to significant mortality, necessitating the development of a vaccine that can handle the virus's high variability and evasion of antibodies.
- The study found that while HVR1 insertions in the virus's envelope protein are rare (0.7% in routine sequencing), 3% of patients demonstrated these insertions, impacting the virus's ability to evade neutralizing antibodies (NAbs).
- HVR1 insertions were shown to be viable in living organisms, affecting antibody sensitivity and suggesting that they play a key role in how HCV escapes immune responses during infection.