Publications by authors named "C S Oleata"
George Robert Siggins: Researcher, musician, surfer, mentor, and friend.
Alcohol Clin Exp Res (Hoboken)
September 2024
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share dysregulated neuroimmune-related pathways. Here, we used our established rat model of comorbid post-traumatic stress disorder (PTSD)/AUD to characterize the interleukin 18 (IL-18) system in the central amygdala (CeA). Male and female rats underwent novel (NOV) and familiar (FAM) shock stress, or no stress (unstressed controls; CTL) followed by voluntary alcohol drinking and PTSD-related behaviors, then all received renewed alcohol access prior to the experiments.
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- Impairments in the HPA axis and increased glucocorticoid receptor (GR) activity in the central amygdala (CeA) are important factors in developing alcohol use disorder (AUD).
- The GR antagonist mifepristone reduces craving and consumption of alcohol in AUD patients and models, affecting GABA transmission in alcohol-dependent rats.
- Female rats show higher GR expression in the CeA than males, suggesting sexual differences in GR regulation, and mifepristone influences GABA signaling in a way that may relate to behaviors associated with AUD.
Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in dependent rats are associated with increased GR signaling and changes in GR-mediated transcriptional activity in the rat central nucleus of the amygdala (CeA). The GR antagonist mifepristone decreases alcohol consumption in dependent rats during acute withdrawal and protracted abstinence.
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- Alcohol use disorder (AUD) and affective disorders, such as PTSD, often co-occur and share similar biological mechanisms that could be targeted for more effective treatment.
- Researchers developed a model using stressed rats to study how different stress contexts affect alcohol consumption and PTSD-like symptoms, observing gender differences in how context impacts drinking behavior.
- Modifying the model to include prior alcohol exposure revealed that while stress impacts drinking and GABA signaling in males, females did not show significant changes, indicating a potential disconnect between PTSD symptoms and AUD vulnerability.