Publications by authors named "C S Navara"
Apolipoprotein E4 ( ) is the leading genetic risk factor for Alzheimer's disease. While most studies examine the role of in aging, imaging, and cognitive assessments reveal that influences brain structure and function as early as infancy. Here, we examined human-relevant cellular phenotypes across neurodevelopment using induced pluripotent stem cell (iPSC) derived cortical and ganglionic eminence organoids (COs and GEOs).
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- The use of living biological samples is crucial for preserving and documenting biological diversity, requiring reliable identification and data association for effective use and exchange of these materials.
- There is currently no standardized naming system for identifying animal biological materials, which can lead to misidentification and data loss.
- A newly proposed naming scheme aims to create unique identifiers for animal cellular materials, particularly for wildlife species, enhancing traceability and supporting long-term conservation efforts and biomedical research.
Infantile spasms, with an incidence of 1.6 to 4.5 per 10,000 live births, are a relentless and devastating childhood epilepsy marked by severe seizures but also leads to lifelong intellectual disability.
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- This study explores how to transform pluripotent stem cells into germ cells, specifically in the common marmoset, enhancing our understanding of germ cell development.
- Researchers established methods to culture induced pluripotent stem cells (iPSCs) that can differentiate into primordial germ cell-like cells (PGCLCs), closely resembling the marmoset's natural germ cells.
- The findings provide valuable insights for future research on human gametogenesis, potentially aiding in preclinical modeling of reproductive development.
Translation of stem cell therapies to the clinic will be most successful following optimization of efficacy and safety in appropriate preclinical model systems. Among available models, nonhuman primates (NHPs) provide the most accurate recapitulation of human anatomy, physiology, genetics and epigenetics. Here, we show that baboon pluripotent cells (PSCs) recapitulate key molecular features of human PSCs with greater accuracy than that found in PSCs from non-primate species such as mice.
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