Publications by authors named "C S Murakami"
Background: Little is known about the survival impacts of mitochondrial status in esophageal squamous cell carcinoma (ESCC) patients who undergo neoadjuvant chemotherapy (NAC) followed by surgery.
Methods: In total, 260 pre-NAC samples from ESCC patients were analyzed. Mitochondrial status was estimated employing an objective, immunohistochemistry-based system (Mito-score).
Article Synopsis
- Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) and phosphatidylethanolamine (PE)-specific PLC (PE-PLC) have been found in mammalian tissue but their specific genes and proteins have been largely unidentified for decades.
- Recent studies indicate that human sphingomyelin synthase 2 (SMS2) exhibits both PC-PLC and PE-PLC activities along with other enzymatic functions, marking it as a significant enzyme with multiple roles.
- In experiments, SMS2 showed substrate selectivity for certain types of phospholipids and was inhibited by specific compounds like D609 and zinc, suggesting its unique enzymatic properties as a potential long-sought mammalian PC
The demand for less hazardous and environmentally friendly surface disinfectants is growing and essential oils may be efficient alternatives. Vapor phase assay is a promising technique which explore the volatility of essential oils for determining the antimicrobial activity. In this study, we modified the conditions of the inverted Petri dish technique to evaluate the minimum inhibitory concentrations (MIC).
View Article and Find Full Text PDFDiacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprise ten isozymes (α-κ) that regulate a wide variety of physiological and pathological events. Recently, we revealed that DGK isozymes use saturated fatty acid (SFA)/monosaturated fatty acid (MUFA)-containing and docosahexaenoic acid (22:6)-containing DG species, but not phosphatidylinositol (PI) turnover-derived 18:0/20:4-DG.
View Article and Find Full Text PDFKikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare condition characterized by benign localized lymphadenopathy and clinical symptoms such as fever, sore throat, odynophagia, and leukopenia. Though the etiology of KFD is unknown, this condition is similar to viral infection, including increased infiltration of activated plasmacytoid dendritic cells. KFD exhibits three histological phases that reflect its progression status: proliferative, necrotic, and xanthomatous lesions.
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