Publications by authors named "C S Mellersh"
Ocular melanosis in the adult Cairn Terrier population within the United Kingdom.
Vet Ophthalmol
September 2024
Article Synopsis
- *Methods: The research involved examining 93 adult Cairn Terriers using various eye tests, including gonioscopy and slit lamp biomicroscopy, conducted by a single veterinarian.
- *Results: About 10% of the dogs showed signs of ocular melanosis, mostly in younger dogs; no advanced stages were found, and it's suggested that routine eye assessments should be part of pre-breeding checks to catch early signs of the disease.
Progressive retinal atrophies (PRAs) are a genetically heterogeneous group of inherited eye diseases that affect over 100 breeds of dog. The initial clinical sign is visual impairment in scotopic conditions, as a consequence of rod photoreceptor cell degeneration. Photopic vision degeneration then follows, due to progression of the disease to the cone photoreceptors, and ultimately results in complete blindness.
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- * A study genotyped these variants in 132 different dog breeds, finding that they are present in multiple breeds, but the frequency of each variant is usually specific to certain subsets of breeds.
- * The data suggests these variants have ancient origins, and breeders might selectively avoid breeding dogs that are homozygous for both variants due to the more severe health issues they cause.
Multiocular defect has been described in different canine breeds, including the Old English Sheepdog. Affected dogs typically present with multiple and various ocular abnormalities. We carried out whole genome sequencing on an Old English Sheepdog that had been diagnosed with hereditary cataracts at the age of five and then referred to a board-certified veterinary ophthalmologist due to owner-reported visual deterioration.
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