An Assessment of Back and Shoulder Postures in Single-Handed Exertions: Expanding Ergonomic Reaching Guidelines to Consider Lumbar Spine Axial Twist.

Occupational applicationsAcross a series of standing single-handed exertions performed at different lateral angles, distances, heights, and loads, lumbar axial twist exceeded an angular threshold of 9° in select exertions. Specifically, 9° of rightward axial twist was exceeded for all exertions performed laterally (90° from the body midline). Additionally, for those at the body midline, 9° of leftward axial twist was exceeded for upward exertions and exertions performed at far distances (tertiary reach envelope).

A framework for decolonising and diversifying biomedical sciences curricula: rediscovery, representation and readiness.

To date, most efforts to decolonise curricula have focussed on the arts and humanities, with many believing that science subjects are objective, unbiased, and unaffected by colonial legacies. However, science is shaped by both contemporary and historical culture. Science has been used to support imperialism, to extract and exploit knowledge and natural resources, and to justify racist and ableist ideologies.

Real-world impact of ivacaftor in people with cystic fibrosis and select ivacaftor-responsive mutations.

Background: Ivacaftor approval was extended to people with cystic fibrosis (CF) with ≥1 of 28 additional ivacaftor-responsive mutations in the USA in 2017 based on preclinical in vitro data. This retrospective, observational study assessed real-world clinical response to ivacaftor in people with CF with ≥1 of these mutations, using data from the US Cystic Fibrosis Foundation Patient Registry.

Methods: Participants aged ≥2 years with ≥1 of 28 eligible mutations initiating ivacaftor between May 2017 and December 2018 were included.

A transthalamic pathway crucial for perception.

Perception is largely supported by cortical processing that involves communication among multiple areas, typically starting with primary sensory cortex and then involving higher order cortices. This communication is served in part by transthalamic (cortico-thalamo-cortical) pathways, which ubiquitously parallel direct corticocortical pathways, but their role in sensory processing has largely remained unexplored. Here, we suggest that transthalamic processing propagates task-relevant information required for correct sensory decisions.

Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA-Encoded Libraries.

Inhibition of poly (ADP-ribose) polymerase-1 (PARP1), a DNA repair enzyme, has proven to be a successful strategy for the treatment of various cancers. With the appropriate selection conditions and protein design, DNA-encoded library (DEL) technology provides a powerful avenue to identify small molecules with the desired mechanism of action towards a target of interest. However, DNA-binding proteins, such as PARP1, can be challenging targets for DEL screening due to non-specific protein-DNA interactions.