Publications by authors named "C S Lair"
Background: This study was designed (1) to compare growth, morbidity and mortality in < 33-week gestational age (GA) (very preterm, VPT) or very low birth weight (BW < 1500 grams, VLBW) infants before (Epoch-1) and after implementing routine enteral zinc (Zn) supplementation (Epoch-2) to meet recommendations, and (2) to assess serum Zn levels and associated variables.
Methods: Single-center prospective cohort of 826 infants. The primary outcome was the change (Δ) in Z-scores of accurate length (Δlength), weight and head circumference from birth to discharge home.
Zinc (Zn) is one of the most prevalent and essential micronutrients, found in 10% of all human proteins and involved in numerous cellular enzymatic pathways. Zn is important in the neonatal brain, due to its involvement in neurotransmission, synaptic plasticity, and neural signaling. It acts as a neuronal modulator and is highly concentrated in certain brain regions, such as the hippocampus, and the retina.
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- The study aimed to create a predictive model for whether infants born preterm or with low birth weight were fed their mother's own milk (MOM) at discharge, focusing on social determinants of health (SDOH) and maternal-neonatal factors.
- It analyzed data from 986 neonates at an inner-city hospital, revealing that feeding MOM was less common among non-Hispanic Black mothers compared to Hispanic mothers, a trend that remained consistent before and after a donor human milk program was introduced.
- The model showed that lower odds of feeding MOM at discharge were linked to factors like higher neighborhood poverty, maternal substance use, and younger maternal age, but these odds did not improve after the implementation of the donor human milk program.
Objective: The primary objectives were to compare body mass index (BMI) Z-score (Z), systolic blood pressure (SBP), serum leptin:adiponectin (L:A) ratio and estimated glomerular filtration rate (eGFR) at ~3 years adjusted age between two arms of a randomized controlled trial (RCT) comparing two modes of human milk fortification for very low-birthweight infants in the neonatal intensive care unit.
Study Design: Follow-up of RCT at 33-48 months.
Results: Follow-up data are available in 82/120 infants.
Objective: Necrotizing enterocolitis (NEC) primarily affects preterm, especially small for gestational age (SGA), infants. This study was designed to (1) describe frequency and timing of NEC in SGA versus non-SGA infants and (2) assess whether NEC is independently associated with the severity of intrauterine growth failure.
Study Design: Retrospective cohort study of infants without severe congenital malformations born <33 weeks' gestational age (GA) carried out from 2009 to 2021.