Publications by authors named "C S Kiser"
Article Synopsis
- The text discusses the characterization of a gene model for the ortholog of a specific gene in the Dyak_CAF1 Genome Assembly, which is documented in GenBank with the accession number GCA_000005975.1.
- This gene model is part of a larger dataset aimed at understanding the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across a particular genus.
- The characterization was conducted using the Genomics Education Partnership's gene annotation protocol as part of undergraduate research experiences.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid plaques, phosphorylated tau tangles and microglia toxicity, resulting in neuronal death and cognitive decline. Since microglia are recognized as one of the key players in the disease, it is crucial to understand how microglia operate in disease conditions and incorporate them into models. The studies on human microglia functions are thought to reflect the post-symptomatic stage of the disease.
View Article and Find Full Text PDFOxygen support plays a critical role in the management of preterm infants in neonatal intensive care units. On the other hand, the possible effects of oxygen supplementation on cellular functions, specifically glucose metabolism, have been less understood. PURPOSE: of the study is to investigate whether supplemental oxygen alters glucose metabolism and pentose phosphate pathway (PPP) activity in the brain tissue and its relevance with silent information regulator proteins (SIRT) pathway.
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- There is a significant lack of understanding regarding how certain Gram-negative bacteria, particularly from the Enterobacterales order, cause severe blood infections (bacteremia) despite their survival strategies being more suited for different environments.
- Enterobacterales species, such as E. coli and Klebsiella pneumoniae, are prevalent in bacteremia cases, often leading to life-threatening conditions like sepsis due to immune system responses.
- Researchers identified 18 key genes linked to the bacteria's survival and tested their effects using mutant strains in a mouse model, discovering several genes whose mutations weakened the bacteria, paving the way for potential new treatments for bloodstream infections.
Microglia are the tissue-resident immune cells of the central nervous system. As a part of the innate immune response, NLR Family Pyrin Domain Containing Protein 3 (NLRP3) inflammasome activation leads to cleavage of caspase-1 and triggers secretion of proinflammatory cytokines and may also result in pyroptotic cell death. Inflammasome activation plays a crucial role in inflammatory conditions; aberrant activation of inflammasome contributes to the pathogenesis of neurodegenerative diseases.
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