Publications by authors named "C S J Teh"

: The emergence and dissemination of carbapenem-resistant organisms, particularly and , pose a significant threat to healthcare systems worldwide. This retrospective study aims to characterise carbapenem-resistant (CRAB) and carbapenem-resistant (CRKP) strains in a teaching hospital and to determine the risk factors associated with patients' in-hospital mortality. : A total of 90 CRAB and 63 CRKP were included in this study.

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  • Venetoclax is a novel drug that improves outcomes for chronic lymphocytic leukemia (CLL) patients, showing that early treatment response can predict long-term success.
  • Researchers used mass cytometry to analyze blood samples from CLL patients and found that venetoclax significantly reduced various CLL cell subpopulations while increasing survival proteins in the remaining cells.
  • The study suggests that CLL cells quickly adapt to therapies through survival signals like the B-cell activating factor (BAFF), indicating that combining treatments might lead to more effective and lasting results.
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Seed vigour is a desirable trait especially for direct seeded rice (DSR) cultivation. Seeds with high vigour could improve seed germination, support seedlings in competing with weeds for water and nutrients, and improving seedling establishment throughout the early stages of crop growth. The success of DSR system which account for more 25% of world cultivation areas is highly dependent on the seed vigour and seedling establishment.

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  • Cognitive impairment is linked to diabetes, but how they affect each other and impact long-term cognitive outcomes, particularly in older adults with cerebrovascular disease, isn't well understood.
  • A study involving 654 participants analyzed brain MRIs and cognitive tests over 5 years, focusing on various cerebrovascular disease markers.
  • Results indicated that diabetes negatively impacts cognitive performance, particularly in individuals with high levels of white matter hyperintensities, rather than functioning independently or significantly affecting Alzheimer biomarkers.
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  • * Four NC-CRKP isolates were sequenced and analyzed, revealing different sequence types and the presence of non-carbapenemase β-lactamase, but no carbapenemase genes were found.
  • * Resistance mechanisms were linked to chromosomal mutations affecting efflux pump proteins and porin loss, highlighting the need for whole-genome sequencing in monitoring carbapenem resistance in clinical settings.
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