The Effect of Preselection on the Level of Bias and Accuracy in a Broiler Breeder Population, a Simulation Study.

Many breeding programmes have to perform preselection, as genotyping and phenotyping all potential breeder candidates is often not a feasible option. There is need to understand how preselection affects the quality of the genomic estimated breeding values (EBVs) at final selection and thereby can affect genetic progress. This simulation study evaluated nine different preselection strategies in a broiler breeder programme and their effect on the quality of the (genomic) EBVs and genetic progress for three different traits: body weight (Body Weight), residual feed intake (RFI) and body weight gain (Gain).

Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression.

Low response rate, treatment relapse, and resistance remain key challenges for cancer treatment with immune checkpoint blockade (ICB). Here we report that loss of specific tumor suppressors (TS) induces an inflammatory response and promotes an immune suppressive tumor microenvironment. Importantly, low expression of these TSs is associated with a higher expression of immune checkpoint inhibitory mediators.

Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study.

Background: The timing of introduction to solid food has been associated with eczema and wheezing in childhood. Our aim was to determine whether differences persist within the recommended 4 to 6 month age range.

Methods: A longitudinal cohort study with repeated measures was conducted among children from birth to 10 years of age who were participating in the TARGet Kids! practice based research network in Toronto, Canada.