Publications by authors named "C S Ghosh"
Environmental abuses and subsequent array of health hazards by petroleum products have emerged as a global concern that warrants proper remediation. Pyrene (PYR), a polycyclic aromatic hydrocarbon, is a xenobiotic by-product during crude petroleum processing. Biodegradation potential of two bacterial isolates (MK4 and MK9) of Brevibacterium sediminis from oil contaminated sites was explored.
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- Focal cortical dysplasia (FCD) is a key cause of hard-to-treat epilepsy, and this study explored how glucose metabolism is affected in different FCD types by studying GLUT1 expression and DNA methylation changes.
- Researchers found that hypermethylation of glucose-regulating genes can differentiate FCD subtypes from other conditions and that lower GLUT1 levels are linked to increased levels of VEGFα and MCT2.
- Decitabine treatment showed potential to restore glucose uptake and alter gene expression related to metabolism in brain cells, suggesting new pathways for developing biomarkers and early treatment strategies for FCD.
Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).
Arterioscler Thromb Vasc Biol
December 2024
Article Synopsis
- Vascular leakage is a serious complication of severe infections like septicemia and malaria, leading to shock and multi-organ dysfunction, with a specific syndrome (MG-CLS) causing recurrent severe episodes triggered by minor infections.
- Researchers identified loss-of-function mutations in the PARP15 gene present in MG-CLS patients, linked to reduced enzyme function and increased vascular leakage.
- The PARP15 enzyme plays a crucial role in protecting blood vessel integrity during inflammation by inhibiting certain pathways, indicating a genetic factor influencing susceptibility to MG-CLS-related vascular issues.
Article Synopsis
- Diabetes ketoacidosis (DKA) is a serious condition primarily affecting individuals with type 1 diabetes, leading to acidic blood and disrupted metabolism due to excess ketones.
- The study discusses a new diagnostic method using a paper-based patch that employs thin film solid-phase microextraction (TF-SPME) to improve the detection of β-hydroxybutyric acid (BHB), a key ketone body.
- Results show that the paper patches made with DVB/PDMS have better extraction efficiency for BHB than other materials tested, offering a highly accurate and straightforward quantification method for this important biomarker.
Vibrio cholerae is an inherent inhabitant of aquatic ecosystems. The Indian state of West Bengal, especially the Gangetic delta region is the highest cholera affected region and is considered as the hub of Asiatic cholera. V.
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