Publications by authors named "C S Garrard"

Article Synopsis
  • Research data management (RDM) is crucial for implementing FAIR and Open Science principles, leading to the development of valuable tools and resources for effective data management in scientific research.
  • Despite the valuable resources produced by ELIXIR Platforms and Nodes, they are currently scattered, creating challenges in their application and dissemination, highlighting the need for coordinated RDM efforts.
  • The proposed ELIXIR RDM Community aims to unify RDM experts, enhance knowledge exchange, provide training, and develop best practices, thereby strengthening RDM skills and addressing the evolving needs within the scientific community.
View Article and Find Full Text PDF
Article Synopsis
  • Arterial agenesis is a rare condition affecting various arteries, including the internal and common carotid arteries, as well as the pulmonary artery, but not previously reported for subclavian arteries.
  • A case of a patient with no symptoms was discovered to have bilateral subclavian artery agenesis and an aneurysm in the left subclavian artery.
  • Though asymptomatic, the aneurysm was surgically repaired to avoid risks of thrombosis, embolism, and stroke.
View Article and Find Full Text PDF

In silico predictive models for toxicology include quantitative structure-activity relationship (QSAR) and physiologically based kinetic (PBK) approaches to predict physico-chemical and ADME properties, toxicological effects and internal exposure. Such models are used to fill data gaps as part of chemical risk assessment. There is a growing need to ensure in silico predictive models for toxicology are available for use and that they are reproducible.

View Article and Find Full Text PDF

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map.

View Article and Find Full Text PDF

Background: Better understanding of patient and family member experiences of delirium and related distress during critical care is required to inform the development of targeted nonpharmacologic interventions.

Objective: To examine and synthesize qualitative data on patient and family member delirium experiences and relieving factors in the Intensive Care Unit (ICU).

Design: We conducted a systematic review and qualitative meta-synthesis.

View Article and Find Full Text PDF