The complex interplay between redox dysregulation and mTOR signaling pathway in cancer: A rationale for cancer treatment.

The mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that plays a critical role in regulating cellular processes such as growth, proliferation, and metabolism in healthy cells. Dysregulation of mTOR signaling and oxidative stress have been implicated in various diseases including cancer. This review aims to provide an overview of the current understanding of mTOR and its involvement in cell survival and the regulation of cancer cell metabolism as well as its complex interplay with reactive oxygen species (ROS).

Handheld Dynamometer for Hamstring Strength Test Using Two Different Hand Placements/Methods: An Interrater Reliability Study.

Handheld dynamometers provide an accurate measurement of muscle strength and have been shown to have good interrater reliability. The proximal stabilization and fulcrum are two methods of manual muscle testing; however, there is uncertainty about which method may be better for obtaining muscle strength measures. The purposes were to determine if there was a difference in hamstring strength and to determine the interrater reliability of DPT students using a handheld dynamometer when comparing the proximal stabilization and the fulcrum methods.

Exploring the Antibacterial and Antiparasitic Activity of Phenylaminonaphthoquinones-Green Synthesis, Biological Evaluation and Computational Study.

Organic compounds with antibacterial and antiparasitic properties are gaining significance for biomedical applications. This study focuses on the solvent-free synthesis (green synthesis) of 1,4-naphthoquinone or 2,3-dichloro-1,4-naphthoquinone with different phenylamines using silica gel as an acid solid support. The study also includes in silico PASS predictions and the discovery of antibacterial and antiparasitic properties of phenylaminonaphthoquinone derivatives -, which can be further applied in drug discovery and development.