Enhanced structural stability of formamidinium lead bromide (FAPbBr) perovskites in confined and coated configurations under varying pressures.

Formamidinium lead bromide (FAPbBr) perovskites are a rapidly emerging class of materials that have the potential to revolutionize optoelectronic and photovoltaic industries. It is now recognized that FAPbBr photoelectronic properties are strongly influenced by the underlying perovskite structure, with static and dynamic disorder among the lattice sites playing prominent roles. We show how these structure-property interactions may be exploited to enhance the photoluminescent properties of FAPbBr by increasing the relative amount of FAPbBr that is exposed to the surface of a substrate material.

Genetic variants of as potential predictors for perineural invasion of prostate cancer in a Taiwanese population.

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), which binds with high affinity to numerous RNA transcripts, is known to promote tumorigenesis and metastasis, including in prostate cancer (PCa). Several case-control studies investigated associations between polymorphisms and cancer progression. However, the effects of genetic variants on clinicopathological progression and biochemical recurrence (BCR) of PCa remain unclear.

Combined Inhibition of Importin-β and PBR Enhances Osteogenic Differentiation of BMSCs by Reducing Nuclear Accumulation of Glucocorticoid Receptor and Promoting Its Mitochondrial Translocation.

Excessive buildup of endogenous glucocorticoids has been closely linked to postmenopausal osteoporosis (PMOP), though the underlying mechanisms remain unclear. This study examines the role of glucocorticoid receptor (GR) signaling in PMOP, particularly its translocation to mitochondria, interaction with the peripheral benzodiazepine receptor (PBR), and impact on bone formation. In vitro, primary bone marrow mesenchymal stem cells (BMSCs) from mice were cultured to induce osteogenesis under varying concentrations of dexamethasone.

Deep learning the flow law of Antarctic ice shelves.

Antarctic ice shelves buttress the grounded ice sheet, mitigating global sea level rise. However, fundamental mechanical properties, such as the ice flow law and viscosity structure, remain under debate. In this work, by leveraging remote-sensing data and physics-informed deep learning, we provide evidence over several ice shelves that the flow law follows a grain size-sensitive composite rheology in the compression zone.