Assessing the metastatic potential of circulating tumor cells using an organ-on-chip model.

Metastatic lung cancer remains a leading cause of death worldwide, with its intricate metastatic cascade posing significant challenges to researchers and clinicians. Despite substantial progress in understanding this cascade, many aspects remain elusive. Microfluidic-based vasculature-on-chip models have emerged as powerful tools in cancer research, enabling the simulation of specific stages of tumor progression.

Effect of Mndoping and DDAB-assisted postpassivation on the structural and optical properties of CsPb(Cl/Br)halide perovskite nanocrystals.

Cesium lead halide perovskite (CsPbX; X = Cl, Br, I) nanocrystals showing intense band-edge emission and high photoluminescence quantum yield are known to be a potential candidate for application in optoelectronic devices. However, controlling toxicity due to the presence of Pbin lead-based halide perovskites is a major challenge for the environment that needs to be tackled cautiously. In this work, we have partially replaced Pbwith Mnions in the CsPb(Cl/Br)nanocrystals and investigated their impact on the structural and optical properties.

Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment.

The combination of cisplatin and pemetrexed remains the gold standard chemotherapy for malignant pleural mesothelioma (MPM), although resistance and poor response pose a significant challenge. Cytidine deaminase (CDA) is a key enzyme in the nucleotide salvage pathway and is involved in the adaptive stress response to chemotherapy. The cytidine analog capecitabine and its metabolite 5'-deoxy-5-fluorocytidine (5'-DFCR) are converted via CDA to 5-fluorouracil, which affects DNA and RNA metabolism.

An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1.

Background: The inducible Kras/p53 lung adenocarcinoma mouse model, which faithfully recapitulates human disease, is routinely initiated by the intratracheal instillation of a virus-based Cre recombinase delivery system. Handling virus-based delivery systems requires elevated biosafety levels, e.g.

Evaluating causative factors for landslide susceptibility along the Imphal-Jiribam railway corridor in the North-Eastern part of India using a GIS-based statistical approach.

The Northeast part of India is experiencing an increase in infrastructure projects as well as landslides. This study aims to prepare the landslide susceptibility map of Tamenglong and Senapati districts, Manipur, India, and evaluates the state of landslide susceptibility along the Imphal-Jiribam railway corridor. Efficient statistical methods such as frequency ratio (FR), information value (IoV), weight of evidence (WoE), and weighted linear combination (WLC) were used in model preparation.