Effect of donepezil on bone metabolism among older adults with Alzheimer's disease.

Older adults with Alzheimer's disease (AD), in addition to significant cognitive disability, have twice the risk of fracture compared to those with normal cognition. Fractures among older adults with AD are associated with substantial morbidity, loss of physical function, and significant mortality. Prior studies have shown a decreased risk of fracture among those taking acetylcholinesterase inhibitors, such as donepezil.

Enabling osteoporosis treatment in post-acute care: An algorithm for providers.

Approximately 60 % of older adults with a hospitalized fracture receive post-acute care in a skilled nursing facility (SNF), yet fewer than 10-20 % receive osteoporosis treatment following a fracture. This study sought to understand SNF providers' perspectives on osteoporosis treatment and to receive feedback on a pocketcard to guide osteoporosis treatment in the post-acute care setting. We interviewed 17 SNF providers with 2+ years of post-acute care experience from 13 states.

Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.

The "Stress Tests and Biomarkers of Resilience" conference, hosted by the American Geriatrics Society and the National Institute on Aging, marks the second in a series aimed at advancing the field of resilience science. Held on March 4-5, 2024, in Bethesda, Maryland, this conference built upon the foundational work from the first conference, which focused on defining resilience across various domains-physical, cognitive, and psychosocial. This year's gathering centered around three factors: the biology that underlies resilient outcomes; the social, environmental, genetic, and psychosocial factors that impact that resilience biology; and the biomarker testing and imaging that predicts resilient outcomes for older adults.