Publications by authors named "C S Cina"
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers, and KRAS mutations occur in 25% to 30% of NSCLC. Our approach to developing a therapeutic with the potential to target KRAS-mutant NSCLC was to identify a new target involved in modulating signaling proteins in the RAS pathway. Glutathione S-transferase P (GSTP), known as a phase II detoxification enzyme, has more recently been identified as a modulator of MAPK-related cell signaling pathways.
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- * Higher levels of procalcitonin (>0.5 ng/mL) were found to be independent risk factors for complications, surgery, and even mortality in these patients.
- * The research suggests that measuring procalcitonin levels in the emergency department could be a valuable tool for risk stratification in managing this condition.
Artificial intelligence (AI) and computer vision (CV) are beginning to impact medicine. While evidence on the clinical value of AI-based solutions for the screening and staging of colorectal cancer (CRC) is mounting, CV and AI applications to enhance the surgical treatment of CRC are still in their early stage. This manuscript introduces key AI concepts to a surgical audience, illustrates fundamental steps to develop CV for surgical applications, and provides a comprehensive overview on the state-of-the-art of AI applications for the treatment of CRC.
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- The study investigates the impact of different histological subtypes of ampullary carcinomas (ACs) on long-term patient outcomes following pancreaticoduodenectomy (PD).
- It includes data from 2004 to 2020, comparing overall survival (OS) and disease-free survival (DFS) among pancreatobiliary (Pb-AC), intestinal (Int-AC), and mixed (Mixed-AC) ACs.
- Results show that Pb-AC patients have significantly worse 5-year OS and DFS compared to Int-AC patients, indicating a more aggressive tumor behavior in Pb-ACs and Mixed-ACs, while Int-ACs demonstrate better survival rates.
Background: Peritoneal metastases carry the worst prognosis among all sites of colorectal cancer (CRC) metastases. In recent years, the advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival for selected patients with limited peritoneal involvement. We report the evolution of CRS and HIPEC for colorectal peritoneal metastases at a tertiary referral center over a 10-year period.
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