Publications by authors named "C S Bray"
Article Synopsis
- Anticoagulant-related nephropathy (ARN) is becoming more recognized as a cause of acute kidney injury (AKI), especially in patients using warfarin, and now also needs scrutiny for direct oral anticoagulants (DOACs).
- A case study showed a 64-year-old male with paroxysmal atrial fibrillation treated with DOACs, presenting with heart failure and AKI, which was linked to kidney damage and underlying IgA nephropathy.
- The findings highlight the need for clinicians to be vigilant about the potential risk of ARN in patients on DOACs, especially when they exhibit symptoms of AKI, emphasizing early diagnosis for better patient outcomes.
Article Synopsis
- Early to mid-life traumatic brain injury (TBI) has been identified as a potential risk factor for developing Alzheimer's disease (AD) and related dementia.
- The study indicates that TBI reduces the expression of BCL2-associated athanogene 3 (BAG3), leading to a chain reaction of cognitive deficits and pathological changes in mice, including hyperphosphorylated tau accumulation and synaptic dysfunction.
- Overexpressing BAG3 specifically in neurons mitigated these AD-like symptoms, suggesting that targeting BAG3 could be a promising therapeutic approach to address TBI-induced cognitive decline.
The changing landscape of geriatric care in acute myeloid leukemia: a 5-year analysis of inpatient mortality predictors, trends in mortality, and chemotherapy use.
Proc (Bayl Univ Med Cent)
July 2024
Background: This study examined inpatient mortality factors in geriatric patients with acute myeloid leukemia (AML) using data from the 2016 to 2020 National Inpatient Sample.
Methods: Identifying patients through ICD-10 codes, a total of 127,985 individuals with AML were classified into age categories as follows: 50.58% were 65 to 74 years, 37.
This study investigated the impact of COVID-19 on patients with sickle cell crisis (SCC) using National Inpatient Sample (NIS) data for the year 2020. A retrospective cohort analysis was conducted utilizing International Classification of Diseases (ICD-10) codes to identify adults who were admitted with a principal diagnosis of sickle cell crisis. The primary outcomes examined were inpatient mortality, while the secondary outcomes assessed included morbidity, hospital length of stay, and resource utilization.
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