Publications by authors named "C Rumeau"
Background: Clinical trials have demonstrated the effectiveness of biologics in treating chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world evidence regarding patient outcomes and predictors of clinical response remains limited.
Methodology: In this multicentric 18-month follow-up study, 326 adult patients who initiated biologic therapy for severe uncontrolled CRSwNP were included.
Background: Necrotizing otitis externa (NOE) is a rare disease associated with high morbidity and mortality, and there is currently no available accurate biomarker to assess treatment responses. The aim of the current study was to evaluate and directly compare the diagnostic performances of 18-Fluoro-deoxyglucose positron emission tomography (F-FDG PET) and labeled leukocyte scintigraphy (LS) to monitor treatment responses in NOE.
Methods: Consecutive patients with NOE who underwent F-FDG PET at the end of antibiotic therapy and planar as well as single photon emission computed tomography-labeled leukocyte scintigraphy after completing the initial antibiotic treatment were retrospectively included.
Article Synopsis
- The study investigates how well conventional MRI and diffusion-weighted MRI can differentiate between mucopyocele and mucocele using surgical outcomes for reference.
- It analyzed data from 74 patients between 2017 and 2024, noting specific MRI signal features, including T1 and T2 signal intensities and diffusion characteristics.
- Results showed distinct differences in T1 signal intensity between the two conditions, with DWI proving to be the most reliable method for diagnosis, including specificities and sensitivities for various MRI signs.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common condition affecting 2% of people, typically treated with corticosteroids and saline rinses, with surgery as an option for those who don't respond to medication.
- In France, two biologic treatments are available for severe cases that don’t improve after existing therapies or surgery, and a new study will evaluate the effectiveness and safety of these biologics in real-life settings.
- The BIOlogics in severe nasal POlyposis SurvEy (BIOPES) is a national, multicenter study aimed at understanding the impact of biologics on CRSwNP patients and gathering various clinical data to inform future treatments.
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission).
Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing.