Publications by authors named "C Rosazza"
Epilepsy, a neurological disorder characterised by recurrent seizures, poses significant challenges in diagnosis, treatment, and management. Understanding the underlying causes and identifying precise anatomical locations of epileptogenic foci are critical for effective management strategies, particularly in drug-resistant patients. Neuroimaging techniques, particularly magnetic resonance (MR), play a pivotal role in the evaluation of epilepsy patients, offering insights into structural abnormalities, epileptogenic lesions, and functional alterations within the brain.
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- The study examines the effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy in improving lung function in people with cystic fibrosis (pwCF), specifically looking at the lung clearance index (LCI) as a sensitive measure.
- 129 pwCF, aged 12-36, were assessed at the start of ETI and after 6 and 12 months, revealing that while most showed significant improvement in lung function measurements (FEV), a small group did not (15.5% had no significant change).
- Those with minimal change in FEV had better initial pulmonary function, yet showed improved LCI values post-treatment, highlighting the LCI's role in evaluating ETI effectiveness
Background: Elexacaftor-tezacaftor-ivacaftor (ETI) is a highly effective cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulating therapy for people with CF and at least one F508del variant. However, there is limited data about the safety and efficacy of this therapy in pediatric populations and in real-world settings. This study aimed at evaluating the effectiveness, tolerability, and safety of ETI in children with CF.
View Article and Find Full Text PDFBackground: People with cystic fibrosis (pwCF) are considered at risk of developing severe forms of respiratory viral infections. We studied the consequences of COVID-19 and virus-host cell interactions in CF vs. non-CF individuals.
View Article and Find Full Text PDFBackground: Children tend to have milder forms of COVID-19 than adults, however post-acute complications have been observed also in the paediatric population. In this study, we compared COVID-19-related outcomes and long-term complications between paediatric and adult patients infected by SARS-CoV-2.
Methods: The study is based on individuals enrolled from October 2020 to June 2021 in the DECO COVID-19 multicentre prospective study supported by the Italian Ministry of Health (COVID-2020-12371781).