Publications by authors named "C Romera"
Background: Mouse brains can contain specific polyglucosan aggregates known as Periodic Acid-Schiff (PAS)-granules. Generated in astrocytes, these granules increase with age and exhibit neo-epitopes of carbohydrate nature that are recognized by natural IgM antibodies (IgMs). The existence of neoepitopes on PAS granules suggests the presence of neoepitopes in other brain structures, and this is investigated here.
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- Wasteosomes (or corpora amylacea) are polyglucosan bodies linked to aging and neurodegenerative diseases, potentially serving a brain cleaning function.
- A study examined wasteosomes in 124 post-mortem FTLD patients across three proteinopathies (tau, TDP, and FUS), finding a higher accumulation in FTLD patients compared to controls, particularly in FTLD-FUS cases.
- Results indicated that while wasteosomes increased with disease duration in FTLD-TDP, they did not show this trend in FTLD-tau and FTLD-FUS, suggesting varying roles in disease progression among the proteinopathies.
The first report of corpora amylacea (CA) is attributed to Morgagni, who described them in the prostate in the eighteenth century. Nearly a hundred years later, and following the lead started by Purkinje, Virchow described them in the brain. He made a detailed description of the most useful techniques to visualize them, but he failed to describe the cause of why CA do appear, why they are mainly linked with the elderly, and which is their clinical significance.
View Article and Find Full Text PDFBrain , recently renamed as wasteosomes, are polyglucosan bodies that appear during aging and some neurodegenerative conditions. They collect waste substances and are part of a brain cleaning mechanism. For decades, studies on their composition have produced inconsistent results and the presence of tau protein in them has been controversial.
View Article and Find Full Text PDFObjective: The assessment of the cardiovascular (CV) risk is recommended in patients with chronic inflammatory rheumatic diseases. The objectives of this study were to assess the CV risk profile in a cohort of patients with psoriatic arthritis (PsA), to determine the presence of subclinical cardiovascular disease by carotid ultrasound (US), and to study the association of CV disease to PsA characteristics.
Methods: This was a cross-sectional multicentric descriptive study.