Publications by authors named "C Roffe"
Article Synopsis
- The study evaluated the safety and efficacy of glyceryl trinitrate (GTN) for patients experiencing transient ischaemic attack (TIA) during stroke trials, as part of the RIGHT-2 trial.
- Conducted as a multicenter, randomized, sham-controlled trial, the research involved administering GTN to patients with suspected ultra-acute stroke and assessing outcomes at 90 days using the modified Rankin Scale (mRS).
- Results showed that while GTN effectively lowered blood pressure, it did not improve functional outcomes or mortality rates compared to the sham treatment, indicating no benefit for TIA patients.
Introduction: Endovascular treatment (EVT) improves outcomes for basilar artery occlusion (BAO) with moderate-to-severe symptoms. However, the best treatment for mild symptoms (NIHSS score 0-10 and 0-5) remains unclear. This study compared EVT ± IVT to IVT alone in BAO patients with mild symptoms.
View Article and Find Full Text PDFIntroduction: The Tranexamic acid for IntraCerebral Haemorrhage-2 (TICH-2) trial reported no significant improvement in death and dependency at day 90 despite reductions in haematoma expansion, early neurological deterioration and early death. However, significant recovery after stroke, particularly intracerebral haemorrhage (ICH), may take more than 3 months. Here we report the participant outcomes at 1 year after stroke.
View Article and Find Full Text PDFBackground And Objectives: An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, including hematoma expansion and hydrocephalus. The Tranexamic acid (TXA) for hyperacute primary IntraCerebral Hemorrhage (TICH-2) trial demonstrated that tranexamic acid (TXA) reduces the risk of hematoma expansion. We hypothesized that TXA would reduce the frequency of surgery (primary outcome) and improve functional outcome at 90 days in surgically treated patients in the TICH-2 data set.
View Article and Find Full Text PDFBackground: Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.
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