Publications by authors named "C Roels"
Article Synopsis
- Komagataella phaffii, formerly known as Pichia pastoris, is widely used for producing recombinant proteins for therapeutics and food, but the original strain NRRL Y-11430 is restricted.
- Researchers identified the NCYC 2543 strain from 1954 as a foundation for developing an open-access strain called OPENPichia, designed to enable widespread use without restrictions.
- By modifying the HOC1 gene in NCYC 2543, the team enhanced its ability to take up DNA and improve protein secretion, providing a genome-sequenced strain and a versatile expression vector toolkit for the biotech community.
Precipitation of hyponatremia and seizures by esmolol in sterile water formulation.
Am J Health Syst Pharm
January 2024
Purpose: Acute hyponatremia can lead to severe neurological symptoms such as confusion, obtundation, seizures, coma, and respiratory depression, contributing to increased morbidity and mortality. Patients with acute hyponatremia should be evaluated based on volume status and serum osmolality to determine potential causes and appropriate treatment. The aim of this case report is to illustrate the importance of using a multidisciplinary approach to evaluate medication formulation and the potential impact on a patient's clinical course.
View Article and Find Full Text PDFBackground: Emergent neuroendovascular stenting presents challenges for the utilization of antiplatelet agents.
Methods: This was a multicenter, retrospective cohort of patients who underwent emergent neuroendovascular stenting. The primary endpoints were thrombotic and bleeding events in relation to the timing of antiplatelet administration, route of administration, and choice of intravenous (IV) agent and the study investigated practice variability in antiplatelet utilization.
Background: Dual antiplatelet therapy (DAPT) is commonly employed for neuroendovascular stenting due to the significant risk of thromboembolism. Clopidogrel and aspirin are most often selected as initial DAPTs; however, there is limited literature available to support guidance of DAPT in this setting. The objective of this study was to evaluate safety and efficacy in patients whose final regimen included either DAPT with aspirin and clopidogrel (DAPT-C) or DAPT with aspirin and ticagrelor (DAPT-T).
View Article and Find Full Text PDFArticle Synopsis
- VHHs are unique antigen binders with potential for therapies, research, and diagnostics due to their small size and stability.
- A structure-guided method was used to identify specific regions in VHHs where N-glycosylation can occur without disrupting protein function or ability to bind to antigens.
- The study revealed that glyco-engineered VHHs can efficiently target macrophages in the lungs, highlighting a promising application for selective drug delivery using these modified proteins.