Publications by authors named "C Rodriguez-Tenreiro"
Assessment of effectiveness and impact of universal prophylaxis with nirsevimab for prevention of hospitalizations due to respiratory syncytial virus in infants. The NIRSE-GAL study protocol.
Hum Vaccin Immunother
December 2024
Article Synopsis
- Nirsevimab has been approved for universal RSV prevention in infants, with a study (NIRSE-GAL) launched in Galicia in September 2023 to assess its effectiveness against various RSV-related health issues.
- The study will monitor infants during the RSV season, focusing on different groups including newborns and those at high risk, and will track outcomes until significant events occur or the study concludes.
- Data analysis will utilize sophisticated models and will include safety monitoring of nirsevimab, with results communicated through scientific publications and conferences.
Article Synopsis
- The study investigates the impact of respiratory syncytial virus (RSV) on infants, highlighting that the effects go beyond just hospitalization and require better understanding for future healthcare planning.
- Researchers analyzed data from 6626 children, comparing those hospitalized with severe RSV to those who weren't, focusing on healthcare visits and prescriptions related to respiratory issues.
- Results showed that severe RSV significantly increased visits to primary healthcare for conditions like wheezing and lower respiratory infections, indicating a substantial burden even after initial hospitalization.
After the use of facemasks, other isolation measures enacted during the SARS-CoV-2 pandemic were lifted, respiratory pathogens, such as RSV, reappeared, but until the November 2023 WHO alert for China, had virtually disappeared. After observing a similar reappearance in our hospital, a retrospective analysis of the number of positive tests. Between 2018 and December 2023, 1619 PCR tests were ordered and 43 (2.
View Article and Find Full Text PDFExtensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.
View Article and Find Full Text PDFBackground: Progressive osseous heteroplasia (POH) is an ultrarare genetic disorder characterized by an inactivating mutation in the gene that causes heterotopic ossification. Inhibition of the mammalian target of the rapamycin (mTOR) signalling pathway has been proposed as a therapy for progressive bone fibrodysplasia and non-genetic forms of bone heteroplasia. Herein, we describe the impact of using Everolimus as a rescue therapy for an identical twin girl exhibiting an aggressive clinical phenotype of POH.
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