Publications by authors named "C Rodriguez Blazquez"
Article Synopsis
- Aggressive large B-cell lymphomas (LBCL) have diverse biological traits; detecting MYC rearrangements (MYCr) is crucial for understanding their prognosis.
- Current recommendations urge performing cytogenetic tests on all aggressive LBCL cases to identify MYCr, but due to its low occurrence, affordable screening options are necessary.
- Researchers developed a scoring system and algorithm based on immunohistochemical profiles of CD10, LMO2, and MYC to effectively screen for MYCr, achieving high sensitivity and predictive values in both training and validation series.
Growth-associated protein of 43 kDa (GAP43) is a key cytoskeleton-associated component of the presynaptic terminal that facilitates neuroplasticity. Downregulation of GAP43 expression has been associated to various psychiatric conditions in humans and evokes hippocampus-dependent memory impairments in mice. Despite the extensive studies conducted on hippocampal GAP43 in past decades, however, very little is known about its roles in modulating the excitatory versus inhibitory balance in other brain regions.
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- CRBN is a component of a protein complex linked to regulating neurotransmission, and mutations in its gene lead to a specific type of intellectual disability in humans, which is mimicked in mouse models.
- Research indicates that the overactivation of the cannabinoid CB receptor in these mouse models is likely responsible for observed memory deficits, suggesting a link to reduced excitatory neurotransmission.
- Targeting the CB receptor with specific blockers shows promise in reversing memory issues, which points to a potential therapeutic approach for treating this form of intellectual disability.
Biomass burning is common in much of the world, and in some areas, residential wood-burning has increased. However, air pollution resulting from biomass burning is an important public health problem. A sampling campaign was carried out between May 2017 and July 2018 in over 64 sites in four sessions, to develop a spatio-temporal land use regression (LUR) model for fine particulate matter (PM) and wood-burning tracers levoglucosan and soluble potassium (K) in a city heavily impacted by wood-burning.
View Article and Find Full Text PDFUnderstanding temporal and spatial trends in pregnancy and birth outcomes within an urban area is important for the monitoring of health indicators of a population. We conducted a retrospective cohort study of all births in the public hospital of Temuco, a medium-sized city in Southern Chile between 2009 and 2016 (n = 17,237). Information on adverse pregnancy and birth outcomes, as well as spatial and maternal characteristics (insurance type, employment, smoking, age, and overweight/obesity), was collected from medical charts.
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