Publications by authors named "C Rocha-de-Souza"
Objectives: Infections due to carbapenemase-producing Enterobacterales harboring more than one carbapenemase-encoding gene spreads mainly by plasmid and transposon mobilization.
Objectives: Analyze the mobile genetic elements carrying bla and bla of K. pneumoniae carbapenemase co-producers (KpKN).
Pseudomonas aeruginosa, an opportunistic pathogen often found in Healthcare-associated infections (HAI), has shown increased resistance to carbapenems (imipenem, meropenem, doripenem), the primary treatment options. We've seen a rise in carbapenemase-producing P. aeruginosa in Brazil, including NDM-producers.
View Article and Find Full Text PDFPolymyxin resistance in Enterobacter cloacae complex in Brazil: phenotypic and molecular characterization.
Braz J Microbiol
December 2024
Article Synopsis
- Enterobacter cloacae complex is a significant multidrug-resistant pathogen found in hospitals, prompting a study on its antimicrobial resistance and genetic factors in Brazil.
- The study screened 94 clinical isolates, finding 20.2% (19 isolates) resistant to colistin, with high levels of resistance indicated by MIC values ranging from 4 to 128 µg/mL.
- Genetic analysis revealed several carbapenemase and polymyxin resistance genes, along with diverse genetic profiles among the isolates, but no predominant clone was established.
Genomic study of strains co-harboring and reveals a large multidrug-resistant plasmid encoding these carbapenemases in Brazil.
Front Microbiol
July 2024
Introduction: contributes significantly to the global issue of multidrug-resistant (MDR) nosocomial infections. Often, these strains demonstrate resistance to carbapenems (MDR-CRAB), the first-line treatment for infections instigated by MDR . Our study focused on the antimicrobial susceptibility and genomic sequences related to plasmids from 12 clinical isolates of that carry both the blaOXA-58 and carbapenemase genes.
View Article and Find Full Text PDFA 7-Year Brazilian National Perspective on Plasmid-Mediated Carbapenem Resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Complex and the Impact of the Coronavirus Disease 2019 Pandemic on Their Occurrence.
Clin Infect Dis
July 2023
Article Synopsis
- Carbapenemase production is a significant global health concern, and analyzing antimicrobial resistance (AMR) data is essential for effective public health policies, as showcased in this study focused on Brazil's AMR Surveillance Network.
- The study evaluated carbapenemase detection rates in Brazilian hospitals from 2015 to 2022, finding trends such as a notable increase in blaNDM detection and a decrease in blaKPC for Enterobacterales, particularly after the onset of the COVID-19 pandemic.
- Overall, the findings highlight the resilience of the AMR Surveillance Network and indicate a concerning shift in carbapenemase profiles, with blaNDM becoming increasingly prevalent.