Publications by authors named "C Robert Horsburgh Jr"
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that imposes significant complications, including diabetic peripheral neuropathy (DPN). DPN is characterized by marked inflammation, and the fibrinogen-to-albumin ratio (FAR) is one of the new markers for systemic inflammation, it has been used in various diabetic micro- and macro-vascular complications. The present study investigates the association between FAR and nerve conduction abnormalities in T2DM patients with DPN.
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- - The study compared the effectiveness of Lumipulse plasma beta-amyloid (Aβ) 42/40 and pTau181 assays to detect abnormal amyloid-PET imaging in individuals with different cognitive states, using samples from 215 participants.
- - Lumipulse and IP-MS Aβ42/40 assays had the best diagnostic accuracy (AUCs of 0.81 and 0.84), while the Simoa Aβ42/40 assay showed the lowest accuracy (AUC of 0.57); combining Aβ42/40 with pTau181 provided no significant performance improvements.
- - Overall, Lumipulse Aβ42/40 and IP-MS performed similarly well in identifying abnormal amy
Introduction: Atypical variants of Alzheimer's disease (AD) include the visual variant, known as posterior cortical atrophy (PCA), and the language variant, known as logopenic progressive aphasia (LPA). Clinically, rates of disease progression differ between them.
Methods: We evaluated 34 PCA and 29 LPA participants.