Ror is a nervous system-specific co-receptor for Wnt ligands.

Wnt ligands are secreted glycoproteins that control many developmental processes and are crucial for homeostasis of numerous tissues in the adult organism. Signal transduction of Wnts involves the binding of Wnts to receptor complexes at the surface of target cells. These receptor complexes are commonly formed between a member of the Frizzled family of seven-pass transmembrane proteins and a co-receptor, which is usually a single-pass transmembrane protein.

Training in Urban Medicine and Public Health: Preparing Physicians to Address Urban Health Care Needs.

Background: Wisconsin is facing significant physician shortages. The University of Wisconsin School of Medicine and Public Health (UWSMPH) launched Training in Urban Medicine and Public Health (TRIUMPH) to recruit and prepare medical students to serve people living within urban Health Professional Shortage Areas.

Methods: Students are selected based on their commitment to improve health equity for urban populations.

The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility.

Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses to Wnts are manifold and are determined by the respective Wnt ligand and its specific receptor complex in the plasma membrane. Wnt receptor complexes contain a member of the Frizzled family of serpentine receptors and a co-receptor, which commonly is a single-pass transmembrane protein.

Bound states in sharply bent waveguides: analytical and experimental approach.

Quantum wires and electromagnetic waveguides possess common features since their physics is described by the same wave equation. We exploit this analogy to investigate experimentally with microwave waveguides and theoretically with the help of an effective potential approach the occurrence of bound states in sharply bent quantum wires. In particular, we compute the bound states, study the features of the transition from a bound to an unbound state caused by the variation of the bending angle, and determine the critical bending angles at which such a transition takes place.

The germinal centre kinase Don3 triggers the dynamic rearrangement of higher-order septin structures during cytokinesis in Ustilago maydis.

The dimorphic phytopathogenic fungus Ustilago maydis grows in its haploid phase by budding. Cytokinesis and separation of daughter cells are accomplished by the consecutive formation of two distinct septa. Here, we show that both septation events involve the dynamic rearrangement of septin assemblies from hourglass-shaped collars into ring-like structures.