Publications by authors named "C Rini"
Background: Aromatase inhibitors (AIs) are a cornerstone of adjuvant systemic therapy for postmenopausal patients with hormone-receptor positive (HR+) breast cancer. Although AIs decrease cancer recurrence rates and improve survival rates, approximately 50 % of patients experience arthralgia-persistent pain related to worse patient outcomes and poor AI adherence. Current medical interventions for AI-associated arthralgia have limited efficacy and side effects that restrict their use among older patients.
View Article and Find Full Text PDFObjective: Most cancer patients undergoing hematopoietic stem cell transplant report elevated symptoms and reduced health-related quality of life during peritransplant. These concerns can become persistent. A prior randomized controlled trial showed that expressive helping-a low-burden, brief intervention combining expressive writing with a novel peer support writing exercise-reduced psychological distress and physical symptoms in long-term transplant survivors with moderate/high persistent symptoms.
View Article and Find Full Text PDFArticle Synopsis
- Family-based RCTs often struggle with recruiting and keeping participants, particularly in cancer research, which usually relies on samples from specific hospitals.
- This study focused on recruiting dyads (patients with prostate cancer and their partners) to evaluate a dyadic eHealth intervention aimed at improving their quality of life, conducted in North Carolina during the COVID-19 pandemic.
- Out of 3,078 patients referred, 280 dyads were randomized, achieving a high enrollment rate (85.11%) and a retention rate of 78.93% over 12 months, with factors like race and age influencing dropout rates.
Purpose: Investigating associations between group-based medical mistrust (GBMM) and perceptions of patient-provider encounters can identify one mechanism through which GBMM may influence health outcomes and serve as a barrier to equitable health care. This study investigated associations between GBMM reported by caregivers of children with a possible genetic condition and caregivers' and providers' perceptions of a specialty care appointment discussing diagnostic plans.
Methods: Caregivers (N = 177) completed the GBMM scale and other measures before their child's initial specialty clinic visit.
Purpose: As population-based screening programs to identify genetic conditions in adults using genomic sequencing (GS) are increasingly available, validated patient-centered outcome measures are needed to understand participants' experience. We aimed to develop and validate an instrument to assess the perceived utility of GS in the context of adult screening.
Methods: Informed by a 5-domain conceptual model, we used a 5-step approach to instrument development and validation: (1) item writing, (2) cognitive testing, (3) pilot testing and item reduction, (4) psychometric testing, and (5) evaluation of construct validity.