Association of Drug Use and Erosive Tooth Wear in Prisoners: A Cross-Sectional Study.

Introduction: The present study evaluated the association between drug use and erosive tooth wear (ETW) in prisoners.

Methods: This is a cross-sectional, descriptive, and analytical research carried out in Southern Brazil. Data collection took place through the application of questionnaires and clinical examination.

Influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts.

The human cytomegalovirus (HCMV) is a common pathogen, which causes severe or even deadly diseases in immunocompromised patients. In addition, congenital HCMV infection represents a major health concern affecting especially the lung tissue of the susceptible individuals. Antivirals are a useful strategy to treat HCMV-caused diseases.

The anti-obesity drug orlistat reveals anti-viral activity.

The administration of drugs to inhibit metabolic pathways not only reduces the risk of obesity-induced diseases in humans but may also hamper the replication of different viral pathogens. In order to investigate the value of the US Food and Drug Administration-approved anti-obesity drug orlistat in view of its anti-viral activity against different human-pathogenic viruses, several anti-viral studies, electron microscopy analyses as well as fatty acid uptake experiments were performed. The results indicate that administrations of non-cytotoxic concentrations of orlistat reduced the replication of coxsackievirus B3 (CVB3) in different cell types significantly.

Characterization of coxsackievirus B3 replication in human umbilical vein endothelial cells.

After successful invasion of susceptible hosts, systemic distribution of coxsackievirus B3 (CVB3) most likely requires interactions with the endothelial system. Thereby, infection of endothelial cells occurs directly or viruses and/or virus-infected leukocytes migrate through the endothelial barrier. Many of these processes have not been studied so far.

Influence of disinfectants on dentin bond strength of different adhesive systems.

The influence of water disinfectants used in dental unit waterlines on the dentin bonding of different adhesive systems was investigated by using push-out tests. Three hundred and twenty dentin disc specimens were prepared from caries-free human molars. In each specimen, a standardized conical cavity was prepared while cooling with water from a dental unit containing one of three different disinfectants (n=80 each group; A=control: water without disinfectant, B: Alpron neutral, C: Alpron mint, D: Dentosept P).