'Do they care?': a qualitative examination of patient perspectives on primary care clinician communication related to opioids in the USA.

Objectives: This substudy's objectives were to (1) examine the transferability of a four archetype framework (simplified pattern of prototypical features) for patients at high risk for opioid use disorder (OUD) developed from a previous study with a similar population; (2) explore how patient preferences for terminology can inform clinician communication strategies for patients with OUD across archetypes and (3) explore how patient perceptions of opioid risks can inform clinician communication strategies across patient archetypes.

Design: This qualitative study collected data via semistructured phone interviews with patients about views on opioid-related discussions with primary care clinicians. Qualitative data were coded using the Rigorous and Accelerated Data Reduction technique and analysed via iterative inductive/deductive thematic analysis.

Recent Incarceration and Minoritized Racial Status as Barriers to the Effectiveness of Recovery Management Checkups.

: Recovery management checkups done in primary care settings (RMC-PCs) can be an effective intervention to link individuals with substance use disorders (SUD) to treatment and help them stay engaged with treatment. There is reason to question, however, whether RMC-PCs are as effective for those who have been recently incarcerated or for those holding a minoritized, racial identity. : We examined data from a randomized controlled trial of RMC-PCs compared to a control condition ( = 266).

Development of a reference standard to assign bacterial versus viral infection etiology using an all-inclusive methodology for comparison of novel diagnostic tool performance.

Background: Diagnostic test evaluation requires a reference standard. We describe an approach for creating a reference standard for acute infection using unrestricted adjudication and apply it to compare biomarker tools.

Methods: Adults and children with suspected acute infection enrolled in three prospective studies at emergency departments and urgent cares were included.

Tuning the selectivity of NH oxidation via cooperative electronic interactions between platinum and copper sites.

Selective catalytic oxidation (SCO) of NH to N is one of the most effective methods used to eliminate NH emissions. However, achieving high conversion over a wide operating temperature range while avoiding over-oxidation to NO remains a significant challenge. Here, we report a bi-metallic surficial catalyst (PtCuO/AlO) with improved Pt atom efficiency that overcomes the limitations of current catalysts.

Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection.

Autophagy plays a crucial role in the host response to Mycobacterium tuberculosis (Mtb) infection, yet the dynamics and regulation of autophagy induction on Mtb-containing vacuoles (MCVs) remain only partially understood. We employed time-lapse confocal microscopy to investigate the recruitment of LC3B (LC3), a key autophagy marker, to MCVs at the single cell level with our newly developed workflow for single cell and single MCV tracking and fluorescence quantification. We show that approximately 70% of MCVs exhibited LC3 recruitment but that was lost in about 40% of those MCVs.