R2DT: a comprehensive platform for visualising RNA secondary structure.

RNA secondary (2D) structure visualisation is an essential tool for understanding RNA function. R2DT is a software package designed to visualise RNA 2D structures in consistent, recognisable, and reproducible layouts. The latest release, R2DT 2.

Description and Classification of Training Drills, Based on Biomechanical and Physiological Load, in Elite Basketball.

The aim of this study was to understand and describe the physiological and biomechanical demands of various tasks used in basketball training and, subsequently, to provide a practical application of these tasks in a typical training week. Twelve basketball players had their external load variables monitored across 179 training sessions (2896 samples) using local positioning system technology. These variables included total distance covered, distance covered at various intensity levels, accelerations, decelerations, PlayerLoad™, and explosive efforts.

High Expression of GABA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma.

Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABA) receptor, which is a ligand-gated ion channel. GABA receptor activation via GABA binding allows for an intracellular influx of Cl ions, thus inducing cellular hyperpolarization. Each GABA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer.

External Physical Demands during Official Under-18 Basketball Games: Consideration of Overtime Periods.

The purpose of this study was to identify the external demands during official under-18 basketball matches that included four quarters (Q1, Q2, Q3, Q4) and/or overtime (OT) periods. Variables included: 1) distance covered and distance covered within four intensity zones (standing-walking S-W, jogging JOG, running RUN, and high-speed running HSR); 2) explosive efforts per minute (EEs); 3) PlayerLoad (PL); 4) the number of jumps per minute; 5) the number of accelerations above 2 m·s2 (ACCs); and 6) the number of decelerations above -2 m·s2 per minute (DECs). The values for total distance, JOG, RUN, HSR, PL, ACC, and DEC were significantly smaller during periods Q2, Q3, Q4, and OT compared to Q1.