Publications by authors named "C Rey-Santano"
Article Synopsis
- Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature newborns, with treatment focusing on supportive care rather than a cure.
- This study examined the effects of a new glucocorticoid, ciclesonide, on lung health and brain effects in a rat model of BPD induced by chorioamnionitis.
- Results showed that ciclesonide treatment improved lung function and structure and reduced pulmonary hypertension without negatively impacting brain development.
Structural and haemodynamic evaluation of less invasive surfactant administration during nasal intermittent positive pressure ventilation in surfactant-deficient newborn piglets.
PLoS One
May 2023
Article Synopsis
- - The study examined the effects of various less-invasive surfactant administration (LISA) methods during non-invasive ventilation (NIV) on neonatal respiratory distress syndrome (RDS) in piglets, aiming to understand the cerebral impacts through near-infrared spectroscopy (NIRS).
- - Five groups of piglets with induced RDS underwent different treatments: control (NIPPV only), INSURE-like surfactant delivery, and three LISA methods using various catheters, revealing that LISA techniques were effective and well-tolerated.
- - Results indicated that the vascular catheter and LISAcath® provided better lung compliance and reduced lung damage compared to other methods, while neither surfactant administration approach significantly affected brain
Background: In recent years, nasal intermittent positive pressure ventilation (NIPPV) has been growing in popularity as a form of noninvasive ventilation for respiratory support in the initial treatment of neonates with surfactant (SF) deficiency. The combination of this type of ventilation with noninvasive SF administration (by nebulization) is an attractive treatment option for respiratory distress syndrome (RDS)-associated pathophysiology of the neonatal lungs. In this study, we aimed to test the tolerability and efficacy of SF nebulization during NIPPV for the treatment of neonatal RDS.
View Article and Find Full Text PDFHemorrhagic shock is one of the leading causes of mortality and morbidity in pediatric trauma. Current treatment based on volume resuscitation is associated to adverse effects, and it has been proposed that vasopressors may be used in the pharmacological management of trauma. Terlipressin has demonstrated its usefulness in other pediatric critical care scenarios and its long half-life allows its use as a bolus in an outpatient critical settings.
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