Publications by authors named "C Reinhardt"
Article Synopsis
- * The study focused on the role of the complement anaphylatoxin C5a in hookworm infection during the early lung stage, revealing that C5aR1 mice had a reduced burden of hookworms and less lung damage compared to regular mice.
- * Results showed that C5aR1 signaling in neutrophils plays a complex role in response to hookworm infections, highlighting an unexpected downside of complement activation in fighting parasites.
The enzyme ribonucleotide reductase plays a critical role in DNA synthesis and repair. Its mechanism requires long-range radical transfer through a series of proton-coupled electron transfer (PCET) steps. Nuclear quantum effects such as zero-point energy, proton delocalization, and hydrogen tunneling are known to be important in PCET.
View Article and Find Full Text PDFPioneer transcription factors (TFs) bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression. Chemical probes are lacking for pioneer TFs, which has hindered their mechanistic investigation in cells. Here, we report the chemical proteomic discovery of electrophilic compounds that stereoselectively and site-specifically bind the pioneer TF forkhead box protein A1 (FOXA1) at a cysteine (C258) within the forkhead DNA-binding domain.
View Article and Find Full Text PDFArticle Synopsis
- Intestinal ischemia-reperfusion (I/R) injury is a severe condition caused by reduced blood flow to the intestines, leading to significant tissue damage and poor health outcomes.
- The study uses a microsurgical model combined with intravital microscopy to observe the behaviors of immune cells (like leukocytes) during I/R injury, particularly focusing on the role of the endothelial PAR1 receptor.
- Results show that mice lacking the PAR1 receptor had less leukocyte adhesion and reduced formation of neutrophil extracellular traps (NETs), suggesting that PAR1 is a critical factor in the inflammatory response during I/R injury.