Publications by authors named "C Reides"
Experimental glaucoma triggers a pro-oxidative and pro-inflammatory state in the rat cornea.
Biochim Biophys Acta Gen Subj
September 2023
Article Synopsis
- Glaucoma affects the ocular surface, prompting a study to explore the cellular mechanisms behind corneal changes using an animal model with elevated intraocular pressure.
- In the experiment, rats underwent procedures to induce glaucoma in one eye, with various oxidative and inflammatory markers assessed across both eyes.
- Results showed increased oxidative stress and inflammation in the glaucomatous eye, while the contralateral eye exhibited an adaptive response, revealing a potential link between oxidative damage and corneal alterations in glaucoma.
Glaucoma is a neurodegenerative disease that affects eye structures and brain areas related to the visual system. Oxidative stress plays a key role in the development and progression of the disease. The aims of the present study were to evaluate the mitochondrial function and its participation in the brain redox metabolism in an experimental glaucoma model.
View Article and Find Full Text PDFThe aim of this study was to elucidate the intracellular sources of oxidant species, the antioxidant response as well as the main signaling pathways involved in the regulation of the redox balance in the primary visual cortex of rats subjected to an experimental glaucoma model. 3-month female Wistar strain rats were operated under a microscope by cauterizing two of the episcleral veins in order to elevate the intraocular pressure (glaucoma group); the control group received a sham procedure. Seven days after surgery, the animals were sacrificed, the brains were carefully removed, and the primary visual cortex was dissected.
View Article and Find Full Text PDFThe aim of the study was to evaluate the time course of the effects of urban air pollutants on the ocular surface, focusing on the morphological changes, the redox balance, and the inflammatory response of the cornea. 8-week-old mice were exposed to urban or filtered air (UA-group and FA-group, respectively) in exposure chambers for 1, 2, 4, and 12 weeks. After each time, the eyes were enucleated and the corneas were isolated for biochemical analysis.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how diesel exhaust particles (DEP) affect oxidative stress and inflammation in human eye cells over 1, 3, and 24-hour exposure periods.
- The results showed that DEP exposure significantly increases reactive oxygen species (ROS) levels, leading to lipid and protein oxidation, along with an initial activation of antioxidant defenses within the cells.
- However, prolonged exposure resulted in decreased cell proliferation and alterations in the antioxidant system, suggesting that DEP exposure can lead to damaging effects on eye cells over time.