Publications by authors named "C Reichman"
Article Synopsis
- * The study introduces a new ELISA protocol that effectively detects antibodies against the Receptor Binding Domain (RBD) of the virus's Spike protein, showing accuracy and versatility compared to commercial assays.
- * This protocol allows for testing using various sample types, including breast milk and dried blood from remote collection, making it ideal for large-scale studies outside of traditional healthcare settings.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is highly contagious and presents a significant public health issue. Current therapies used to treat coronavirus disease 2019 (COVID-19) include monoclonal antibody cocktail, convalescent plasma, antivirals, immunomodulators, and anticoagulants. The vaccines from Pfizer and Moderna have recently been authorized for emergency use, which are invaluable for the prevention of SARS-CoV-2 infection.
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- * This study presents an ELISA protocol that detects antibodies to the virus and is both accurate and versatile, performing well compared to established commercial tests.
- * The ELISA can utilize various types of biospecimens, including blood and breast milk, and is suitable for remote sample collection, making it ideal for large-scale studies beyond healthcare environments.
Article Synopsis
- Phosphatidylserine (PS)-targeting monoclonal antibodies (mAbs) have been in development for treating infectious diseases and cancer for over a decade, focusing on both pathogens and stressed tumor cells.
- The study explored how two PS-targeting mAbs, 11.31 and bavituximab, affect T cell activation and cytokine production, using activated human T cells as the model.
- While both mAbs bind selectively to activated T cells, only 11.31 was found to suppress the production of certain cytokines (IFN-γ and TNF-ɑ), indicating distinct functional roles and mechanisms of the two mAbs.
Background: Patients with sickle cell disease (SCD) experience significant medical and psychological stressors that affect their mental health, well-being, and disease outcomes. Digital cognitive behavioral therapy (CBT) has been used in other patient populations and has demonstrated clinical benefits. Although evidence-based, nonpharmacological interventions for pain management are widely used in other populations, these treatments have not been well studied in SCD.
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