Publications by authors named "C Reese"
Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) are among the most devastating pests of orchards, nurseries, and forest ecosystems. Anisandrus maiche (Kurentzov) has been regularly captured in ethanol-baited traps along woody edges of apple (Malus domestica (Suckow) Borkh.) orchards in western New York alongside a known apple pest, Xylosandrus germanus (Blandford).
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- The study suggests that insulin resistance in the liver is a key factor leading to dysfunction in pancreatic islets, which is linked to Type 2 Diabetes Mellitus (T2DM) and Metabolic Associated Steatotic Liver Disease (MASLD).
- Researchers developed a microphysiological system combining liver and pancreatic models to better understand how these organ dysfunctions relate to each other. This system allows for the investigation of changes that occur when metabolic syndrome is present.
- Results showed that under metabolic syndrome conditions, the liver-pancreas system exhibited altered insulin secretion and signaling, indicating a direct connection between liver issues and islet dysfunction, which could help in developing personalized treatment strategies for affected patients.
Article Synopsis
- - MASLD is a global health issue affecting around 30% of the population, caused by a mix of genetics, lifestyle, and environmental factors, posing challenges for treatment development due to patient variability.
- - Creating effective therapeutic models is difficult because existing systems and animal models fail to fully reflect the complexities of MASLD progression, prompting the need for more precise experimental approaches.
- - The study utilized a liver acinus microphysiology system (LAMPS) with patient-derived cells to explore the effects of the PNPLA3 genetic variant on MASLD and tested the drug resmetirom, revealing significant changes in liver cell behavior indicative of disease progression.
Article Synopsis
- Caveolin-1 (CAV-1) is a protein that inhibits various kinases and regulates inflammation, and its downregulation in psoriatic skin cells increases inflammation and cell growth.
- A study found that a peptide derived from CAV-1, called sB, was more effective than other modified peptides at reducing symptoms in a psoriasis model, improving skin condition and reducing immune cell infiltration.
- sB not only suppressed signaling pathways associated with inflammation but also inhibited new blood vessel formation, making it a promising therapeutic option for treating psoriasis.