Publications by authors named "C Ray Chandler"

The Green Heart Project is a controlled, community-based clinical trial to evaluate the effects of increasing greenery on community health. The study was initiated in 2018 in a low-to-middle-income residential area of nearly 30,000 racially diverse residents in Louisville, KY. Community engagement was maintained throughout the project, with feedback integrated into its design and implementation.

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Purpose: In response to disparities in COVID-19 vaccine uptake in urban environments, we ascertained whether a community-engaged evaluation could rapidly determine why unvaccinated Chicago residents were hesitant to receive the COVID-19 vaccine.

Approach: The assessment used a mixed-methods approach, grounded in community-based participatory research (CBPR) principles.

Setting: Interviews were conducted by community partners between April and May 2022 in Chicago, in-person and via phone.

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The emergence of fungal antimicrobial resistance-fAMR-is having a growing impact on human and animal health, and food security. This roadmap charts inter-related actions that will enhance our ability to mitigate the risk of fAMR. As humanity's reliance on antifungal chemicals escalates, our understanding of their one-health consequences needs to scale accordingly if we are to protect our ability to manage the global spectrum of fungal disease sustainably.

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Article Synopsis
  • Identifying new adjuvants to make vaccines more effective is crucial, with one promising method being the use of TLR9 agonists like CpG ODNs to boost dendritic cell function.
  • D-15800, a specific D-peptide isomer, has been found to better stimulate the production of the immune response mediator IL-12p70 and promote differentiation of monocytes into dendritic cells compared to its L-isomer counterpart.
  • When combined with TLR9 agonists, D-15800 not only activates immune cells like CD4 T and natural killer cells but also enhances interferon-alpha production, indicating it could significantly improve vaccine outcomes.
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