Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors.

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate tusamitamab ravtansine specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand this specificity, here we map the epitope-paratope interface between the A3-B3 domains of hCEACAM5 (hCEACAM5) and the antigen-binding fragment of tusamitamab (tusa Fab).

Climate Change and Insects.

Climate change (CC) poses one of the foremost challenges for humanity in the 21st century [...

Recent Advances and Best Practices for Cryo-EM Analysis for Protein Structure Determination.

ARTICLES DISCUSSED: de Martin Garrido, N., Ramlaul, K., Aylett, C.

Tomato Leaf Curl New Delhi Virus Spain Strain Is Not Transmitted by and Is Inefficiently Transmitted by Mediterranean between Zucchini and the Wild Cucurbit .

Tomato leaf curl New Delhi virus (ToLCNDV) is a bipartite begomovirus (genus , family ) persistently transmitted, as with all other begomoviruses, by whiteflies (Hemiptera: Aleyrodidae) of the cryptic species complex. The virus, originally from the Indian subcontinent, was recently introduced in the Mediterranean basin, where it is currently a major concern for protected and open-field horticulture. The Mediterranean ToLCNDV isolates belong to a novel strain named "Spain strain" (ToLCNDV-ES), which infects zucchini and other cucurbit crops but is poorly adapted to tomato.

Life history parameters of Bemisia tabaci MED (Hemiptera: Aleyrodidae) in the present and future climate of central Europe, predicted by physically realistic climatic chamber simulation.

Whiteflies of the Bemisia tabaci species complex are among the most damaging insect pests in agriculture worldwide, causing damage by feeding on crop plants and by vectoring plant viruses. The species complex consists of over 35 cryptic species that differ in many aspects of their biology including the optimal environment, geographic distribution, and host range. Global warming and associated climate change resulting from human activities is expected to contribute to biological invasions.