Publications by authors named "C Ramakrishnan"
Motor output results from the coordinated activity of neural circuits distributed across multiple brain regions that convey information to the spinal cord via descending motor pathways. Yet the organizational logic through which supraspinal systems target discrete components of spinal motor circuits remains unclear. Here, using viral transsynaptic tracing along with serial two-photon tomography, we have generated a whole-brain map of monosynaptic inputs to spinal V1 interneurons, a major inhibitory population involved in motor control.
View Article and Find Full Text PDFBackground: Web-based advance care planning (ACP) interventions offer a promising solution to improve ACP engagement, but none are specifically designed to meet the needs of patients with heart failure and their caregivers.
Objective: We aimed to develop and assess the usability and acceptability of a web-based ACP decision aid called "My Voice," which is tailored for patients with heart failure and their caregivers.
Methods: This study's team and advisory board codeveloped the content for both patient and caregiver modules in "My Voice.
Neuronal activity promotes the proliferation of healthy oligodendrocyte precursor cells (OPC) and their malignant counterparts, gliomas. Many gliomas arise from and closely resemble oligodendroglial lineage precursors, including diffuse midline glioma (DMG), a cancer affecting midline structures such as the thalamus, brainstem and spinal cord. In DMG, glutamatergic and GABAergic neuronal activity promotes progression through both paracrine signaling and through bona-fide neuron-to-glioma synapses.
View Article and Find Full Text PDFObjective: The study aimed to assess coronavirus disease 2019 (COVID-19) knowledge among dental patients seeking treatment at a tertiary care center.
Materials And Methods: A cross-sectional study was conducted at the Government Dental College Thrissur to assess dental patients' COVID-19 awareness. Patients over 18 who attended the dental department and agreed to participate were included after obtaining the informed consent.
Article Synopsis
- A population of neurons in the ventral tegmental area (VTA) co-transmit two neurotransmitters, glutamate and GABA, but their inputs and functions are not fully understood.
- Using advanced tracing techniques in mice, researchers discovered that these neurons receive diverse inputs from various brain regions, with significant inputs from the superior colliculus and lateral hypothalamus.
- Optical activation of these inputs revealed that lateral hypothalamus involvement leads to active behavior, while superior colliculus stimulation results in brief activation and freezing behavior, indicating the complex integration of signals by VTA neurons related to motivation and behavior.