Publications by authors named "C Rabec"

Unexplained dyspnoea is defined as a chronic (≥ 3 months) and significant (mMRC ≥ 2) dyspnoea without a diagnosis after clinical examination, chest X-ray, biological work-up and electrocardiogram. This condition affects 15 % of patients with dyspnoea and is associated with prolonged diagnostic delay and difficulties in patient referral. This article presents the definition and epidemiology of unexplained dyspnoea, as well as the useful elements of the history and clinical examination.

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Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive diaphragm weakness and deteriorating lung function. Bulbar involvement and cough weakness contribute to respiratory morbidity and mortality. ALS-related respiratory failure significantly affects quality of life and is the leading cause of death.

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Background: Non-invasive ventilation (NIV) is a standard of care for hypercapnic chronic respiratory failure (CRF). Obstructive sleep apnea syndrome (OSA) frequently contributes to hypoventilation in CRF patients. CPAP improves hypercapnia in selected COPD and obese patients, like NIV.

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Background: Thoraco-abdominal asynchrony (TAA) is usually assessed by respiratory inductance plethysmography. The main parameter used for its assessment is the calculation of the phase angle based on Lissajous plots. However, there are some mathematical limitations to its use.

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Article Synopsis
  • COVID-19, caused by the SARS-CoV-2 virus first identified in Wuhan in December 2019, has developed into the largest pandemic in a century, primarily affecting the lungs but also impacting multiple organs.
  • Evidence indicates that COVID-19 can lead to complications in the heart, brain, kidneys, and gastrointestinal system, highlighting its systemic nature and variances in symptom presentation and severity.
  • This review aims to explore the non-pulmonary effects of COVID-19, emphasizing the underlying mechanisms and clinical manifestations associated with these complications.
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