Publications by authors named "C ROUSSO"
Ethnic differences in the root to crown ratios of the permanent dentition.
Orthod Craniofac Res
May 2019
Objective: Root resorption due to orthodontic tooth movement may adversely affect the root-crown (R/C) ratios of permanent teeth, especially in patients with Short Root Anomaly (SRA), a poorly understood disorder affecting root development. Evaluation of SRA R/C ratios to normal dentition would facilitate diagnosis and orthodontic treatment planning. However, reference values are not available for all ethnicities.
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- Resistance to oncolytic virotherapy often happens when tumor cells can't be infected by the virus, leading to treatment failure.
- Dimethyl fumarate (DMF), used for psoriasis and multiple sclerosis, shows potential anticancer effects by enhancing viral infection in cancer cell lines and human tumor samples.
- DMF works by inhibiting type I interferon production and affecting the transcription factor NF-κB, leading to better therapeutic results in resistant tumor models and demonstrating the benefits of repurposing FDA-approved drugs for cancer treatment.
Article Synopsis
- * A new strategy combines OVs with vanadium-based protein tyrosine phosphatase inhibitors, which enhances OV infection and boosts antitumor effects in resistant tumor cell lines and models.
- * This combination alters the immune response from a protective to a pro-inflammatory type, improving viral spread and cancer cell killing, and suggests a promising direction for better immunotherapy approaches.
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.
View Article and Find Full Text PDFThe expression of HLA-DC antigens on peripheral blood mononuclear cells, in tonsil and lymph node tissue sections, on tumor cell lines, and on activated T cells was studied using monoclonal antibody, anti-Leu 10. Anti-Leu 10 reacts with HLA-DC molecules on homozygous B cell lines expressing HLA-DR 1,2,4,5,6,8, and 9. It reacts with heterozygous B lymphocytes expressing DR7 and DRw10, suggesting it also recognizes HLA-DC molecules linked to DRw10.
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