Rising Burden of Colon and Rectum Cancer in China: An Analysis of Trends, Gender Disparities, and Projections to 2030.

Background: Colon and rectum cancer (CRC) is a major health burden in China, with notable gender disparities. This study was designed to analyze trends in CRC incidence, prevalence, and mortality from 1990 to 2021 and to project future trends.

Methods: Using data from the Global Burden of Disease (GBD) Study 2021, we examined CRC burden in China, including incidence, prevalence, mortality, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs).

The efficacy and safety of suvemcitug, envafolimab, and FOLFIRI in microsatellite-stable or mismatch repair-proficient colorectal cancer: preliminary results of a phase 2 study.

Purpose: This phase II study is designed to evaluate the combination therapy involving suvemcitug and envafolimab with FOLFIRI in microsatellite-stable or mismatch repair-proficient (MSS/pMMR) colorectal cancer (CRC) in the second-line treatment setting.

Methods: This study is a non-randomized, open-label prospective study comprising multiple cohorts (NCT05148195). Here, we only report the data from the CRC cohort.

Erratum - Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells .

This corrects the article published in European Journal of Histochemistry 2024;68:4140 doi: 10.4081/ejh.2024.

Multifunctional applications enabled by tunable multi-emission and ultra-broadband VIS-NIR luminescence energy transfer in Sn/Mn-doped lead-free Zn-based metal halides.

Metal halides are widely applied in solid-state lighting (SSL), optoelectronic devices, information encryption, and near-infrared (NIR) detection due to their superior photoelectric properties and tunable emission. However, single-component phosphors that can be efficiently excited by light-emitting diode (LED) chips and cover both the visible (VIS) and NIR emission regions are still very rare. To address this issue, (TPA)ZnBr:Sn/Mn (TPA = [(CHCHCH)N]) phosphors were synthesized by using the solvent evaporation method.

Nanoscopic acoustic vibrational dynamics of a single virus captured by ultrafast spectroscopy.

The natural vibrational frequencies of biological particles such as viruses and bacteria encode critical information about their mechanical and biological states as they interact with their local environment and undergo structural evolution. However, detecting and tracking these vibrations within a biological context at the single particle level has remained elusive. In this study, we track the vibrational motions of single, unlabeled virus particles under ambient conditions using ultrafast spectroscopy.