Publications by authors named "C R WOMACK"
Article Synopsis
- Wildfires are a growing contributor to air pollution, particularly due to reactive organic compounds (ROC), which have varying health impacts based on their toxicity and abundance.
- A study combining field campaign data and air quality modeling found that current emissions estimates capture only 40-45% of the total ROC released from wildfires.
- The research indicates that particulate ROC could significantly affect health risks from smoke exposure, highlighting the need for more accurate toxicity data on these compounds.
The development of drug resistance in cancer cells poses a significant challenge for treatment, with nearly 90% of cancer-related deaths attributed to it. Over 50% of ovarian cancer patients and 30-40% of breast cancer patients exhibit resistance to therapies such as Taxol. Previous literature has shown that cytotoxic cancer therapies and ionizing radiation damage tumors, prompting cancer cells to exploit the autotaxin (ATX)-lysophosphatidic acid (LPA)-lysophosphatidic acid receptor (LPAR) signaling axis to enhance survival pathways, thus reducing treatment efficacy.
View Article and Find Full Text PDFCognitive impairment is a common problem in the geriatric population and is characterized by variable symptoms of memory difficulties, executive dysfunction, language or visuospatial problems, and behavioral changes. It is imperative that primary care clinicians recognize and differentiate the variable symptoms associated with cognitive impairment from changes attributable to normal aging or secondary to other medical conditions. A thorough evaluation for potentially reversible causes of dementia is required before diagnosis with a neurodegenerative dementia.
View Article and Find Full Text PDFMutations in the SWI/SNF chromatin remodeling complex occur in ~20% of cancers. In rhabdoid tumors defined by loss of the SWI/SNF subunit , dysregulation of enhancer-mediated gene expression is pivotal in driving oncogenesis. Enhancer dysregulation in this setting is tied to retention of the SWI/SNF ATPase BRG1-which becomes essential in the absence of -but precisely how BRG1 contributes to this process remains unknown.
View Article and Find Full Text PDFArticle Synopsis
- The objective is to update recommendations for preventing and treating glucocorticoid-induced osteoporosis (GIOP) in patients on glucocorticoids for more than three months at doses of 2.5 mg daily or higher.
- A systematic review was conducted to address various treatment approaches, assessing the quality of evidence and reaching a consensus on recommendations for fracture risk assessment and appropriate therapies.
- The guidelines emphasize early assessment of fracture risk, strongly advise pharmacologic treatment for high-risk individuals, and provide tailored recommendations for specific populations, while ensuring these guidelines do not restrict access to necessary therapies.