Publications by authors named "C R Pant"
Antibiotic Resistance Pattern in Intensive Care Unit of a Tertiary Care Hospital, Nepal.
Kathmandu Univ Med J (KUMJ)
September 2024
Article Synopsis
- - The study focuses on antibiotic resistance patterns of Gram-negative bacteria, particularly in an Intensive Care Unit (ICU) setting, highlighting the critical need to monitor and address this issue due to high rates of bacterial infections in critically ill patients.
- - A total of 500 samples were analyzed over 18 months, with 451 samples showing growth; Escherichia coli was identified as the most prevalent organism, exhibiting significant resistance to standard antibiotics, especially Ciprofloxacin.
- - The findings suggest that Escherichia coli's resistance to commonly used antibiotics limits treatment options, emphasizing the necessity for ongoing surveillance and strict infection control measures in healthcare facilities, especially in ICU areas.
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder that affects dopamine neurons, leading to motor dysfunction, with mitochondria and α-synuclein being key factors in disease progression.
- Research shows that 2,4-dihydroxy-azaflavanone (azaflavanone) has protective effects in PD models, acting as a stronger allosteric activator of SIRT1 compared to resveratrol.
- Azaflavanone enhances mitochondrial function and biogenesis by increasing SIRT1 activity, which helps improve mitochondrial health disrupted by Parkinson's-related conditions.
Article Synopsis
- Mycobacterium tuberculosis (Mtb) modifies its metabolism to thrive in host cells, focusing on the protein Rv0547c, which targets the mitochondria of host cells.
- Rv0547c enhances mitochondrial membrane fluidity and respiratory capacity, independent of its predicted targeting sequence, by influencing lipid composition and fatty acid metabolism.
- The study demonstrates that Rv0547c increases Mtb's persistence during macrophage infection and helps the bacteria survive under stressful conditions by optimizing mitochondrial functions.
Article Synopsis
- Gujarat has experienced significant urbanization over the past two decades, affecting local environments and potentially altering mosquito species' behaviors, prompting a study on their bionomics.
- A systematic study was conducted in Kheda and Panchmahal Districts, where various mosquito collection methods were used to analyze species composition, behavior, and insecticide resistance, revealing six species with a dominant one showing indoor resting habits and zoophagic behavior.
- The study found a concerning level of resistance to a common insecticide and highlighted the early biting behavior of the main malaria vector, indicating a need for regular monitoring and improved vector control measures to combat malaria effectively in the region.
The adsorption of thymine, a key pyrimidine base of deoxyribonucleic acid (DNA) on montmorillonite clay (Mnt) exchanged with metal ions (Mnt-M, M = Fe, Co, Cu, Ca, and Mg) over a range of concentration (7.0 × 10 M to 12.0 × 10 M) and pH (4.
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